2020.12.30 15:35 "Re: [Tiff] Multithreading support?", by John

I meant to add, there are quite a few libraries which wrap libtiff to give fast, high-level access to large TIFFs from languages like R and Python. You could potentially save yourself a lot of work if one of them meets your requirements.

gdal is the obvious one, but there's also libvips, openimageio, etc. etc., and all should have no trouble with your 50gb files.

John